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well, as you don't have the savegame anymore, there isn't much we can do really. all I can say I have never encountered anything like that before (the game freezing/pausing as soon as you enter the irradiated water, and unpausing after the player dies - did I get that right?).
I never heard of this one. Could be a problem that only happens with the Wineskin wrapper of course, although at least one person seems to have beaten the game that way. Does this only happen in the radiated water? What happened when entering radiated areas elsewhere, eg on the Engineering deck?