If I decided to replace looping or single sound effect files with custom files that were 2-3 minutes long, would that cause an issue? For instance, say I created a sound file that played for 2-3 minutes every time the player got wounded or pressed a button - is it ok for me to do that or will it f--k something up? Thanks for any information.

The only acceptable use case for this kind of mod would be to replace the "toxic hazard" voice sound with some sort of "why am I toxic" DSP remix